This means you can carry the box with you to future floors if you wish to take advantage of a certain floor’s effects, all of which are listed in the section below. It will spawn a different combination of pickups or pedestal items depending on what your current floor and chapter are (you can hold tab to see what the current stage is called Basement I, Utero II, Cathedral, etc.).Its one-time use nature means it will disappear after the first use, so decide carefully when to open it up! It is unlocked by beating Dark Room as Lazarus for the first time, and once unlocked, it will show up in the Red Chest and Shop item pools on future runs as well in as the Greed/Greedier mode shops. – is a one-time use item that takes up the Active slot.The basics of Pandora’s Box (if you’re already familiar with the item, you can skip this)
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